Targeted Drug Delivery Systems for Chronic Liver Disease Treatment

Chronic liver diseases (CLDs) that can result from factors such as metabolic disorders, hepatitis, chronic alcohol abuse, drug-induced toxicities, autoimmune disorders have become a significant global health crisis. Despite the growing prevalence of CLDS globally, there are minimal therapeutic options available.

The Menon Lab is trying to address the challenges associated with treating CLDs by developing drug delivery systems that can target cells that drive disease progression while simultaneously delivering therapies that can reduce inflammation and scarring.

Selected Publications

A Novel Kupffer cell-targeting Nanoparticle System to Mitigate Alcohol-associated Liver Disease
Unagolla JM, Flanagan R, Perera K, Kim Y, Soloff C, Kaye E, Slitt A, Menon JU*. Biomaterials 2025: 123623 [DOI]

Targeting Chronic Liver Diseases: Molecular Markers, Drug Delivery Strategies and Future Perspectives
Unagolla JM, Das S, Flanagan, R, Oehler, M, Menon JU*. Int J Pharm 2024. 660. 124381 [DOI]